منابع مشابه
Death and Destruction
teins interfere with apoptosis induced by the action of Fas ligand on immune cells, but no inhibitor of granzyme B activity was previously known. Andrade reported that the rate of binding of 100K to GrB was diffusionlimited, and that the proteins bound with high affinity. But cleavage occurred so slowly that the half-life of the complex averaged 3 hours. If a critical 100K aspartate was mutated...
متن کاملCell Death and Destruction
Upon contact with their bacterial targets, neutrophils fire a barrage of antimicrobial peptides, sometimes releasing structures called neutrophil-associated extracellular traps, or NETs. In releasing their NETs, they commit suicide—unleashing their entire antibacterial arsenal via a specialized form of programmed cell death called netosis. Hakkim et al. (2011) now provide new insight into the m...
متن کاملEcology: Death and Destruction Determine Diversity
Death can be good, bad or indifferent for biodiversity. New work confirms that predators can drive diversification of prey even in homogeneous environments, but suggests that this effect is crucially dependent upon the frequency and intensity of other mass-mortality events.
متن کاملHabitat destruction: death by a thousand cuts
Humankind has dramatically transformed much of the Earth’s surface and its natural ecosystems. This process is not new—it has been ongoing for millennia—but it has accelerated sharply over the last two centuries, and especially in the last several decades. Today, the loss and degradation of natural habitats can be likened to a war of attrition. Many natural ecosystems are being progressively ra...
متن کاملThe destruction of oak by the death-watch beetle.
CERTAIN of the oak timbers of Rothamsted House were recently found to be extensively damaged by wood-boring insects, the damage being ascribed chiefly to the death-watch beetle (Xestobium rufovillosum).' The timbers are believed to be of great age, and some were probably used in an earlier building. In 1623 the house was extensively altered and the exposed timbering of the original house covere...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2001
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1541mr